Advanced Breast Cancer Symptoms | Advanced Cancer Symptoms | Advanced Lung Cancer Symptoms

There are several indications of a locally advanced breast cancer: a stage 3 cancer, with a size larger than two inches and metastasis in lymph nodes, skin inflammation, or a large group of lymph nodes involved in armpit, or you might hit the chest muscle, or skin ulcers.

All these are indications that breast cancer is likely to have spread to other parts of the body, at least under the microscope and thus, when discovered, surgery is not always the first step. lymph node sampling is not necessary. There is often a question of whether wide excision is still possible. If you have very large breasts may be, but if your breasts are small, surgeons may not be able to get enough surrounding tissue out without a mastectomy. The tumor is stuck in the chest muscle or ulcer in the breast skin, immediate local treatment would not be possible at all, remove the entire muscle or skin that is sore I could not leave enough fabric to sew together again .

Advanced Breast Cancer | Aggressive Cancer

Tamoxifen has been used to treat advanced breast cancer for 30 years and has been the first line hormonal treatment of choice for much of this period. It is well tolerated and inexpensive, and serious side effects are rare. Survival rates are equivalent to those of chemotherapy, and although initial response rates are lower, offering a superior quality of life in initial response. Tamoxifen should not be displaced as a key therapy for advanced breast cancer without substantial and convincing data of large randomized trials. Response rates depend on the selection of patients and are higher for patients with tumors sensitive to estrogen.

Tamoxifen alone has an efficacy similar to that of estrogen or progestin when used alone or in combination, but it is better tolerated than most alternative endocrine therapies. In premenopausal women there is good evidence that the combination of tamoxifen and luteinizing hormone releasing hormone (LHRH) analogue is superior to either agent alone. This benefit of hormonal therapy with tamoxifen combination does not necessarily translate to post-menopausal patients. Recently, aromatase inhibitors, the third generation have been compared with tamoxifen in postmenopausal women with advanced breast cancer and has demonstrated superior efficacy, possibly with fewer side effects.